Lanadelumab significantly reduces HAE attacks in long-term use: Study

This research gathered information from the Adelphi Wave II Disease Specific Programme™, a cross-sectional, real-world survey of doctors and their HAE patients in the US, between January 2023 and January 2024. Physicians retrospectively recorded the frequency, severity, and quality of life of attacks prior to starting lanadelumab, as well as at 12, 24, and 36 months after starting the medication and throughout the survey.

Data on 51 patients who had been on lanadelumab for at least 3 years were reported by doctors. At 36 months after starting lanadelumab, 62.5% of patients had mild attacks, and none had very severe attacks in the year prior. Prior to starting lanadelumab, doctors reported that 49.0% of patients had mild attacks and 8.2% had very severe attacks.

Prior to starting lanadelumab, 54.0% of patients reported having at least one attack per month on average; at the time of the survey, that number had dropped to 9.8%. Before starting lanadelumab, 68.6% of patients had good or excellent quality of life; by the time of the survey, that number had risen to 88.2%.

Overall, patients receiving lanadelumab for at least 3 years saw improvements in attack frequency, disease severity, and quality of life in this real-world HAE research. After long-term usage, the percentage of patients who experienced monthly attacks decreased from 54% before therapy to just 9.8%.

Source:

Lumry, W. R., Davis-Lorton, M., Soteres, D., Earl, L., Wynne-Cattanach, K., Fox, D., Sing, K., Juethner, S., & Schultz, B. G. (2025). Long-term real-world outcomes in patients with hereditary angioedema receiving lanadelumab for 3 or more years. International Archives of Allergy and Immunology, 1–18. https://doi.org/10.1159/000546987