Low-Cost Malaria Vaccine found Efficacious in The Lancet Journal study
ICMR Seeks Partners for Malaria Vaccine Commercialisation
In a recent development, the R21/Matrix-M malaria vaccine has demonstrated remarkable efficacy, surpassing 75% in a phase 3 trial involving over 4800 children across four African countries. This significant milestone in the fight against malaria holds the potential to alleviate the burden of the disease in sub-Saharan Africa.
This study was published in The Lancet journal by Mehreen S Datoo and colleagues. The study not only validates the vaccine's effectiveness but also highlights its safety and widespread acceptance, with several African countries already licensing it.
Key Study Details:
Design: Double-blind, randomized, phase 3 trial conducted across five sites in four African countries.
Participants: Enrolled children aged 5–36 months, randomly assigned to receive R21/Matrix-M or a control rabies vaccine.
Dosing: Three doses administered 4 weeks apart, with a booster at 12 months.
Endpoints: Primary objective focused on protective efficacy at seasonal and standard sites over 12 months after completing the primary series.
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