Low-dose ketamine shows promise for pain relief in emergency department patients, finds study

Pain remains one of the most common and challenging complaints among patients presenting to the emergency department (ED). For individuals with opioid tolerance, achieving effective pain relief can be particularly difficult, as they often require higher doses of opioids, which increases risks of hyperalgesia and withdrawal symptoms. In their randomized, placebo-controlled trial, lead author Stine Fjendbo Galili, MD, and colleagues explored the effectiveness of LDK as an adjunct to morphine in a diverse ED population with varying levels of opioid use. The study demonstrated that a single dose of 0.1 mg/kg of ketamine provided significant reductions in pain scores for 30 minutes compared to a placebo.

The study concluded that LDK may be an effective short-term adjunct analgesic to morphine for managing acute pain, offering relief to both opioid-tolerant and opioid-naïve patients. Importantly, the findings open the door for future research to refine low-dose ketamine administration methods, such as bolus or continuous infusions, to achieve longer-lasting pain relief. 

Reference:

Stine Fjendbo Galili, Bodil Hammer Bech, Hans Kirkegaard, Low-dose ketamine as an adjunct to morphine: A randomized controlled trial among patients with and without current opioid use, Academic Emergency Medicine, https://doi.org/10.1111/acem.14983