Moderate-to-vigorous physical activity reduces hyperuricemia risk: PLOS ONE

The analysis revealed a U-shaped relationship between MVPA levels and the risk of HUA. Also, the participants with MVPA levels between 933 and 3423 metabolic equivalent (MET) minutes per week expressed a lower risk of developing HUA. Within this range, the risk was lowest at approximately 1556 MET-minutes per week. Further, the individuals with low activity levels (< 600 MET-minutes per week) had a higher risk of HUA, with an OR of 1.13 (95% CI, 1.02–1.26) when compared to the moderate activity group (600–2999 MET-minutes per week).

These findings suggest that maintaining a certain level of physical activity could be beneficial in preventing hyperuricemia. Also, engaging in MVPA within the range of 933 to 3423 MET-minutes per week appears to be optimal, with the lowest risk of HUA observed around 1556 MET-minutes per week. This translates to approximately 150 to 300 minutes of moderate-intensity exercise per week, which aligns with the general physical activity guidelines for adults.

The U-shaped curve indicates that both insufficient and excessive physical activity could be associated with higher risks of HUA that highlights the importance of a balanced approach to exercise. Overall, this study contributes valuable insights into the prevention of hyperuricemia through physical activity. For individuals who want to reduce their risk of HUA, engaging in moderate levels of physical activity appears to be key.

Source:

Zeng, X., Huang, J., Shen, T., Xu, Y., Yan, X., Li, Q., Li, Y., Xing, X., Chen, Q., & Yang, W. (2024). Nonlinear dose-response association of moderate-to-vigorous physical activity with hyperuricemia in US adults: NHANES 2007–2018. In Y. Nishida (Ed.), PLOS ONE (Vol. 19, Issue 5, p. e0302410). Public Library of Science (PLoS). https://doi.org/10.1371/journal.pone.0302410