nCPAP effectively reduces hypoxia among obese patients undergoing sedated endoscopy: Study
A new study published in the Clinical Gastroenterology and Hepatology journal found that the use of nasal continuous positive airway pressure (nCPAP) significantly lowers the risk of hypoxia in obese patients undergoing sedated upper gastrointestinal (GI) endoscopy, compared to standard oxygen delivery via nasal cannula (NC).
This study was conducted prospectively on 158 adults with a body mass index (BMI) of 30 kg/m² or higher to evaluate whether nCPAP could offer superior respiratory support during elective upper GI endoscopies performed under propofol sedation. Participants were randomized into two groups where one received standard oxygen supplementation through a nasal cannula, and the other received nCPAP throughout the procedure.
The primary endpoint was the incidence of oxygen desaturation, where the blood oxygen saturation (SpO₂) dropping below 90%. The results revealed that only 7.6% of patients in the nCPAP group experienced desaturation, when compared to 25.3% in the NC group.
Secondary outcomes also favored the nCPAP group. The patients using nCPAP maintained a higher minimum oxygen saturation during the procedure (97.1% ± 2.0) than those in the NC group (95.9% ± 2.7), with this difference also achieving statistical significance (p=0.007).
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