Prenatal antibiotic exposure may trigger atopic march, finds study
The atopic march refers to a progression of allergic diseases as they develop over the course of infancy and childhood.
Prenatal antibiotic exposure may trigger atopic march, finds a new study.However more research is needed to determine if prenatal antibiotic exposure triggers atopic march according to the latest study published in the journal Allergy.
Antibiotic use during pregnancy may increase the risk for asthma in children. We performed a meta-analysis assessing prenatal antibiotic exposure and the risk for childhood wheeze or asthma, as well as for diseases associated with the atopic march.
A systematic literature search protocol was registered and searches were completed using Medline, Proquest, Embase, and the Cochrane central register of controlled trials. Screening for inclusion criteria: published in English, German, French, Dutch, or Arabic, intervention (use of any antibiotic at any time point during pregnancy), and disease (reporting atopic disease incidence in children with a primary outcome of asthma or wheeze), and exclusion criteria: reviews, preclinical data, and descriptive studies, yielded 27 studies. Study quality was assessed using the Newcastle–Ottawa Assessment Scale. The quality of the evidence was assessed using the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) approach.
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