Psilocybin significantly reduces major depressive disorder symptoms: Lancet
A new study by Robin von Rotz and team shows that for at least two weeks, a single modest dose of psilocybin dramatically lowers depressed symptoms. The findings of this study were published in eClinical medicine.
Psilocybin has been proposed as a unique, fast-acting depression therapy. Two consecutive doses have been proven to considerably lessen symptom severity in an open-label scenario or when compared to a waiting list group. To the best of the researchers' knowledge, no other trial has compared a single moderate dose of psilocybin to a placebo condition; thus, the primary goal of this randomized clinical trial was to investigate the effect of a single moderate dose of psilocybin versus placebo (equal time spent with psychological support in both treatment conditions) in patients with major depressive disorder (MDD).
In this double-blind, randomized clinical experiment, 52 people with major depressive illness and no unstable somatic problems were randomly assigned to receive either a single, moderate dosage (0.215 mg/kg body weight) of psilocybin or placebo, along with psychological support. MADRS and BDI scores were used to quantify depression severity, with primary outcomes defined as changes from baseline to 14 days following the intervention. The experiment was held in the psychiatric university hospital in Zürich, Switzerland, between April 11th, 2019 and October 12th, 2021.
Disclaimer: This website is primarily for healthcare professionals. The content here does not replace medical advice and should not be used as medical, diagnostic, endorsement, treatment, or prescription advice. Medical science evolves rapidly, and we strive to keep our information current. If you find any discrepancies, please contact us at corrections@medicaldialogues.in. Read our Correction Policy here. Nothing here should be used as a substitute for medical advice, diagnosis, or treatment. We do not endorse any healthcare advice that contradicts a physician's guidance. Use of this site is subject to our Terms of Use, Privacy Policy, and Advertisement Policy. For more details, read our Full Disclaimer here.
NOTE: Join us in combating medical misinformation. If you encounter a questionable health, medical, or medical education claim, email us at factcheck@medicaldialogues.in for evaluation.