Reinfection by COVID-19 common in healthy young adults, finds study
Written By : Dr Kartikeya Kohli
Medically Reviewed By : Dr. Kamal Kant Kohli
Published On 2021-02-02 06:30 GMT | Update On 2022-03-10 09:31 GMT
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Although antibodies induced by infection to COVID-19 are largely protective, they do not guarantee effective immunity against subsequent infection.
Scientists from the Icahn School of Medicine at Mount Sinai, in collaboration with researchers from the Naval Medical Research Center have found in a longitudinal, prospective cohort study that Seropositive young adults for COVID 19 had about one-fifth the risk of subsequent infection compared with seronegative individuals. Findings suggest that COVID-19 vaccination may be necessary for control of the pandemic in previously infected young adults.The study has appeared at medRxiv, preprint server for health sciences.
The researchers utilized the COVID-19 Health Action Response for Marines (CHARM) to examine how protective detectable antibodies are preventing subsequent infections with SARS-CoV-2, the virus that causes COVID-19.
The study population consisted of 3,249 predominantly male, 18-20-year-old Marine recruits who, upon arrival at a Marine-supervised two-week quarantine prior to entering basic training, were assessed for baseline SARS-CoV-2 IgG seropositivity (defined as a 1:150 dilution or greater on receptor binding domain and full-length spike protein enzyme-linked immunosorbent [ELISA] assays.) The presence of SARS-CoV-2 was assessed by PCR at initiation, middle and end of quarantine. After appropriate exclusions, including participants with a positive PCR during quarantine, the study team performed three bi-weekly PCR tests in both seronegative and seropositive groups once recruits left quarantine and entered basic training.
For further reference log on to:
doi: https://doi.org/10.1101/2021.01.26.21250535
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