Risk of Hyponatremia associated with use of Thiazide Diuretics higher than anticipated

Medically Reviewed By : Dr. Kamal Kant Kohli

Published On 2023-12-26 15:00 GMT | Update On 2023-12-27 06:11 GMT

A recent study by Niklas Worm Andersson and team found that the treatment initiation with thiazide diuretics increases the potential risk for hyponatremia, particularly during the initial months of treatment. Based on a population and register-based cohort, the findings were published in the Annals of Internal Medicine.

Thiazide-induced hyponatremia is a condition characterized by low levels of sodium. This is an elusive concern as the existing drug labels suggest it to be rare, occurring at rate less than 1 in 10,000.

This study was conducted in Denmark from January 2014 to October 2018 which aimed to estimate the cumulative incidence of hyponatremia. The research focused on individuals aged 40 years or older with no recent prescription for antihypertensive drugs and no previous hyponatremia. Th research team compared the new use of bendroflumethiazide (BFZ) with a calcium-channel blocker (CCB) and the new use of hydrochlorothiazide plus a renin–angiotensin system inhibitor (HCTZ–RASi) with RASi alone.

Among the 37,786 BFZ users, the outcomes of this study highlighted that the 2-year cumulative incidence of hyponatremia was 3.83% when compared to 3.51% for HCTZ–RASi. The risk differences of 1.35% was found between BFZ and CCB and 1.38% between HCTZ–RASi and RASi respectively. Also, the hazard ratios of the BFZ was 3.56 and HCTZ–RASi was 4.25 in the first 30 days. The study highlighted the outcome of increased substantial risk during the initial months of diuretics treatment.

The implications of the study challenges the existing understanding of the safety profile of thiazide diuretics specially regarding hyponatremia. The excess risk identified were particularly in the early stages of treatment that calls for a reevaluation of prescribing practices and heightened awareness among healthcare providers.

Source:

Andersson, N. W., Wohlfahrt, J., Feenstra, B., Hviid, A., Melbye, M., & Lund, M. (2023). Cumulative Incidence of Thiazide-Induced Hyponatremia. In Annals of Internal Medicine. American College of Physicians. https://doi.org/10.7326/m23-1989

Article Source : Annals of Internal Medicine

Disclaimer: This website is primarily for healthcare professionals. The content here does not replace medical advice and should not be used as medical, diagnostic, endorsement, treatment, or prescription advice. Medical science evolves rapidly, and we strive to keep our information current. If you find any discrepancies, please contact us at corrections@medicaldialogues.in. Read our Correction Policy here. Nothing here should be used as a substitute for medical advice, diagnosis, or treatment. We do not endorse any healthcare advice that contradicts a physician's guidance. Use of this site is subject to our Terms of Use, Privacy Policy, and Advertisement Policy. For more details, read our Full Disclaimer here.

NOTE: Join us in combating medical misinformation. If you encounter a questionable health, medical, or medical education claim, email us at factcheck@medicaldialogues.in for evaluation.

Jacinthlyn Sylvia

Jacinthlyn Sylvia, a Neuroscience Master's graduate from Chennai has worked extensively in deciphering the neurobiology of cognition and motor control in aging. She also has spread-out exposure to Neurosurgery from her Bachelor’s. She is currently involved in active Neuro-Oncology research. She is an upcoming neuroscientist with a fiery passion for writing. Her news cover at Medical Dialogues feature recent discoveries and updates from the healthcare and biomedical research fields. She can be reached at editorial@medicaldialogues.in

Comments Policy

Our comments section is governed by our Comments Policy . By posting comments at Medical Dialogues you automatically agree with our Comments Policy , Terms And Conditions and Privacy Policy .

Risk of Hyponatremia associated with use of Thiazide Diuretics higher than anticipated

Similar News

JAMA Study Questions Routine Prophylactic Antibiotics use for Upper-GI Bleeding in Cirrhosis

FDA Grants Priority Review to Gepotidacin for Gonorrhea Treatment

Laser therapy enhances treatment of fungus resistant to conventional medication, reports research

Heart Failure in Women: Updates from the National Consensus on Bisoprolol

Vitamin D Deficiency Linked to Multiple Diabetic Complications: Study

Is the 'love hormone,' oxytocin, also the 'friendship hormone'?

No Clear Winner: Three Dual-Drug Hypertension Therapies Work Equally Well in Indian Adults, TOPSPIN Trial Finds

Fetal Embolization Exhibits Early Success in High-Risk Vein of Galen Malformation: JAMA