Serum Hepcidin-25 Independently Predicts Mortality in Maintenance Hemodialysis patients: Study

With this background, a prospective observational cohort study was carried out by the Department of Nephrology at the Xuzhou Medical University, China to investigate the associations between hepcidin-25 and mortality in MHD patients.

A total of 161 patients undergoing Maintenance Haemodialysis were included in the study, with a 2 year follow-up. The median value of baseline serum hepcidin-25 was 31.0 (12.1, 57.3) ng/mL. So, the patients were divided into two groups - low-level hepcidin-25 group, and high-level hepcidin-25 group. The relationships between various variables including serum hepcidin-25, demographic characteristics as well as certain other clinical parameters, was investigated.

The study revealed that the serum iron, serum ferritin, transferrin saturation (TSAT), and hsCRP were higher, pre-dialysis creatinine and albumin were lower, and the scores of health-related qualities of life were worse in the high-level hepcidin-25 group than in the low-level hepcidin-25 group. The patients with hepcidin-25< 31 ng/mL had better survival outcomes during the 24-month follow-up. It was also evident that serum hepcidin-25 was associated with ferritin, TSAT, and all-cause mortality.

"Serum hepcidin-25 was associated with ferritin and TSAT, and could be an independent predictor for all-cause mortality in MHD patients. Further research with larger sample size and longer-term follow-up is still needed," the investigators concluded.

Reference:

Study titled, "Serum Hepcidin-25 and All-Cause Mortality in Patients Undergoing Maintenance Hemodialysis," as published in Dovepress.

DOI: https://doi.org/10.2147/IJGM.S313777