Study finds no association between inflammatory disease and risk of Alzheimer's disease

USA: A recent study showed that patients in the Health and Retirement Study (HRS) with common immune-mediated inflammatory diseases (IMID) were not at an increased risk of Alzheimer's disease (AD) over a 6-year period.

The study was published in the journal BMC Rheumatology on 12 November 2021. 

Immune-mediated inflammatory diseases are characterized by systemic inflammation that affects joints and healthy organ systems. Previous studies examining the association between individual IMIDs and the risk of Alzheimer's disease have produced mixed results. Michael J. Booth, University of Michigan, MI, USA, and colleagues, therefore, aimed to examine AD risk across a group of IMIDs in a large population-based sample of older adults. 

The researchers draw data from the HRS on a national sample of US adults over age 50 and linked Medicare claims from 2006 to 2014. IMIDs include psoriatic arthritis, rheumatoid arthritis, ankylosing spondylitis, Crohn's disease, ulcerative colitis, and related conditions. They identified IMIDs from 2006 to 2009 Medicare claims using International Classification of Diseases (ICD9-CM) codes. IMIDs were identified from 2006 to 2009 Medicare claims using International Classification of Diseases (ICD9-CM) codes. The risk of AD was examined from 2009 to 2014.