Subclinical Hyperthyroidism Enhances Metformin's Impact on Gonadotropins in Postmenopausal Women: Study Finds
Poland: A recent study published in The Journal of Clinical Pharmacology revealed that subclinical hyperthyroidism may amplify the gonadotropin-lowering effects of metformin in postmenopausal women. This finding highlights the interplay between thyroid function and metabolic regulation, particularly in diabetes treatment.
The research examined the impact of metformin on various hormonal levels in postmenopausal women diagnosed with subclinical hyperthyroidism. It found that metformin did not affect the circulating levels of TSH, total and free thyroxine, total and free triiodothyronine, estradiol, prolactin, adrenocorticotropic hormone (ACTH), or insulin-like growth factor-1 (IGF-1).
Metformin treatment reduces elevated levels of anterior pituitary hormones. Considering this, Robert Krysiak, Department of Internal Medicine and Clinical Pharmacology, Medical University of Silesia, Katowice, Poland, and colleagues aim to investigate whether hyperthyroidism modulates the impact of metformin on gonadotroph secretory function in a prospective, cohort study.
For this purpose, the researchers included a study population of 48 postmenopausal women with untreated type 2 diabetes or prediabetes, 24 of whom had coexisting grade 1 subclinical hyperthyroidism. Both groups were matched based on age, insulin sensitivity, and gonadotropin levels. Throughout the study, all participants received metformin treatment at a daily dosage of 2.55 to 3 grams.
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