Switching to integrase inhibitor may accelerate weight gain during menopause inHIV patients: Study

Written By : Aditi

Medically Reviewed By : Dr. Kamal Kant Kohli

Published On 2024-03-26 14:45 GMT | Update On 2024-03-27 04:13 GMT

Integrase strand transfer inhibitors (INSTIs) are associated with more significant weight gain in women with HIV (WWH) compared to men with HIV. Menopausal transition leads to changes in body composition.

A finding published in CROI, Conference on Retroviruses and Opportunistic Infections, mentioned that switching to INSTIs during the late peri- and postmenopausal phase is associated with increased waist circumference (WC) and BMI. It was found that following this switch, peak effects occurred around 41 months.

More data is needed on whether INSTI initiation during the menopausal transition affects WC and BMI trajectories.

This study included 1159 women with HIV who were non-pregnant and virally suppressed between 2006 and 2019. Four hundred twenty-four women switched to an INSTI during the study period, while 735 did not. Nine hundred-four women without HIV (WWOH) from the Women’s Interagency HIV Study were included. The visit at which they reported switching was defined as the index visit. The researchers used mixed effect models with quadratic terms to analyze changes in waist circumference and BMI by menopausal phase, as determined by anti-Müllerian hormone levels at the index visit. This hormone is a biomarker of ovarian reserve. The models were adjusted for demographic, baseline measurements, behavioural and comorbidity, and HIV-related factors.

Key findings from the study are:

66% identified as Black, 28% were premenopausal, 10% were early peri-, 28% were late peri-, and 34% were postmenopausal at the index. INSTI+ were older than INSTI- and WWOH, with median BMIs of 30 vs 29 vs 31.5kg/m2, respectively.
64% of INSTI+ and 79% of INSTI- were on tenofovir DF before the index visit.
In premenopausal women, INSTI+ and INSTI—were associated with a 0.06cm per 6 months and 0.08cm per 6 months faster linear increase in WC, respectively, compared to WWOH; INSTI+ had a 0.05cm per 6 months faster increase than INSTI-.
When compared to WWOH, In late perimenopausal women, INSTI+ had faster increases in WC, which peaked at 41mo and then declined.
INSTI—had smaller increases in WC, while INSTI+ had a 0.39cm per 6mo faster linear increase in WC than INSTI-.
In postmenopausal women, INSTI+ was associated with faster WC increases up to 39mo, then declines compared to INSTI-.
BMI trajectories were similar for late peri- and postmenopausal women.

Concluding further, Switching to an INSTI-based regimen during late peri- and postmenopause is tied to early accelerated increases in Waist circumference and BMI when compared to women who did not switch.

The results of this study suggest that menopausal status should be considered when switching to an INSTI.

Article Source : Conference on Retroviruses and Opportunistic Infections,

Disclaimer: This website is primarily for healthcare professionals. The content here does not replace medical advice and should not be used as medical, diagnostic, endorsement, treatment, or prescription advice. Medical science evolves rapidly, and we strive to keep our information current. If you find any discrepancies, please contact us at corrections@medicaldialogues.in. Read our Correction Policy here. Nothing here should be used as a substitute for medical advice, diagnosis, or treatment. We do not endorse any healthcare advice that contradicts a physician's guidance. Use of this site is subject to our Terms of Use, Privacy Policy, and Advertisement Policy. For more details, read our Full Disclaimer here.

NOTE: Join us in combating medical misinformation. If you encounter a questionable health, medical, or medical education claim, email us at factcheck@medicaldialogues.in for evaluation.

Aditi

Dr. Aditi Yadav is a BDS, MDS in Periodontics and Implantology. She has a clinical experience of 5 years as a laser dental surgeon. She also has a Diploma in clinical research and pharmacovigilance and is a Certified data scientist. She is currently working as a content developer in e-health services. Dr. Yadav has a keen interest in Medical Journalism and is actively involved in Medical Research writing.

Comments Policy

Our comments section is governed by our Comments Policy . By posting comments at Medical Dialogues you automatically agree with our Comments Policy , Terms And Conditions and Privacy Policy .

Switching to integrase inhibitor may accelerate weight gain during menopause inHIV patients: Study

Similar News

Tirzepatide superior to Semaglutide- SURMOUNT-5 Trial Results

Hearing Loss Risk Significantly Higher in People With Type 2 Diabetes, reveals research

7-day antibiotic regimen good enough for tackling bacteremia and reducing length of hospitalization: Study

WHO Advises Against Routine Antibiotic Use in COVID-19 Cases Without Bacterial Infection

Atopic eczema associated with lymphopenia, regardless of immunosuppressive drug use: Study

Red Cell Distribution Width-to-Albumin Ratio Shows Nonlinear Link With Retinopathy Risk: Study

Long-Term Passive Smoking Doubles COPD Risk in Women, Study Finds

Sunlight Exposure May Reduce Risk of Postoperative Hypoparathyroidism, suggests study