TyG index closely associated with progression of depression

A recent study published in the Journal of Nutrition, Metabolism, and Cardiovascular Diseases found that baseline triglyceride glucose (TyG) index is closely associated with progression of depression. Also, from a metabolic perspective, TyG index monitoring requires more attention for mental health managements.

Cerebral symptoms are common among individuals with non-communicable conditions, while the longitudinal association between triglyceride glucose (TyG) index, indicator of metabolic health, and progression of depression remains unclear. So, this study by Lan Zheng and team aimed to check the association of birth TyG indicator and depression progression in middle-aged and elder grown-ups.

This retrospective cohort study from the National China Health and Retirement Longitudinal Study in visit 1 (2011–2012), they were biennially followed for depression score until visit 4 (2017–2018). The study included 8287 participants over 45 years and 3806 (45.9%) were men.

Multivariate-adjusted regression models were used to evaluate baseline TyG index and its association with the individual level change rate and slope of depression score.

There was no significant difference of depression score at baseline across TyG quartile groups. Compared to those in the lowest, participants in the highest quartile of TyG index had a 0.124 higher change rate of depression score, and a 0.127 higher change slope.

The associations observed were consistent throughout regardless of multiple sensitivity analyses, and stable in men, the elder, and people suffering overweight.

The findings of this study strongly suggest that TyG index is positively associated with progression of depression specially in men, the elders and  in obese people, this new insights might help in the primary prevention of depression.

Reference:

Zheng, L., Cui, C., Yue, S., Yan, H., Zhang, T., Ding, M., Sun, Q., He, C., & Ren, H. (2022). Longitudinal association between triglyceride glucose index and depression progression in middle-aged and elder adults: A national retrospective cohort study. Nutrition, Metabolism, and Cardiovascular Diseases: NMCD. https://doi.org/10.1016/j.numecd.2022.11.015