Vitamin D may help prevent COVID-19 induced preeclampsia or hypertension: Study

A group of researchers conducted a study to examine the role of Vitamin D in covid-19 induced pregnancy complications.

The pregnancy is considered a physiological condition, that is accompanied by hypervolemia, increased cardiac output, and a diminished total peripheral resistance, still, the pregnants are normotensive, and blood pressure even tends to decrease in the second trimester. Estrogen and progesterone raise angiotensinogen and renin levels, which in turn leads to increased angiotensin II levels, the increased concentration of angiotensinogen, angiotensin II, indicate the increased activity of RAAS, but instead, there is a decrease in systemic vascular resistance characterizes the hemodynamics of the normal pregnancy

SARS-CoV-2 enters target cells via the ACE2 receptor and downregulates them. ACE2 exhibits high catalytic activity to produce Angiotensin 1–7 (Ang-1–7), which has a vasodilator effect and also inactivates the vasoconstrictor Angiotensin II. In normal pregnancy, ACE2 expression is raised in the uterus and placenta. Ang-1–7 levels in plasma are significantly higher in third-trimester pregnant women when compared to non-pregnant women.