Spider venom may be effective pain relief option without side-effects

Molecules in tarantula venom could hold the key to unlocking  an effective and safe pain killer  that is as powerful as opioids without side-effects including addiction.

University of Queensland researchers have designed a novel tarantula venom mini-protein that can potentially relieve severe pain without addiction.

Pain management in chronic patients is a clinical challenge. Chronic pain is often inadequately controlled in patients with cancer and in those with non-cancer chronic pain because successful long-term treatment is more difficult than for acute pain. Opioids are the current standard of care for the treatment of moderate or severe nociceptive pain. They are effective options but with possibility of addiction or abuse. 

Dr Christina Schroeder from UQ's Institute for Molecular Bioscience said the current opioid crisis around the world meant urgent alternatives to morphine and morphine-like drugs, such as fentanyl and oxycodone, were desperately needed.

"Although opioids are effective in producing pain relief, they come with unwanted side-effects like nausea, constipation and the risk of addiction, placing a huge burden on society," Dr Schroeder said.

"Our study found that a mini-protein in tarantula venom from the Chinese bird spider, known as Huwentoxin-IV, binds to pain receptors in the body.

"By using a three-pronged approach in our drug design that incorporates the mini-protein, its receptor and the surrounding membrane from the spider venom, we've altered this mini-protein resulting in greater potency and specificity for specific pain receptors.

"This ensures that just the right amount of the mini-protein attaches itself to the receptor and the cell membrane surrounding the pain receptors."

Dr Schroeder said the mini-protein had been tested in mouse models and shown to work effectively.

"Our findings could potentially lead to an alternative method of treating pain without the side-effects and reduce many individuals' reliance on opioids for pain relief," she said.

for further references log on to: 

http://dx.doi.org/10.1074/jbc.RA119.012281