Merck KGaA to focus on its oncology business
Advertisement
After the falling business of its flagship drug Rebif, used for multiple sclerosis, Merck KGaA is now betting its fortunes on its oncology business to reverse the situation.
The company is now in the stage of a rapid evolution considering the 80% focus on the oncology and immune-oncology drug business, as implied by the company spekesperson.
Rebif has taken a slow dip in the market as there is an increases competition from a new generation of oral drugs.
Amidst the growing participation from the company's workers in the R&D, the company is optimistic on its fortunes any time soon. At the forefront of the cancer research is the drug, avelumab , a treatment that harnesses the power of immune system.
In addition to Rebif and cancer drug Erbitux, which were partially developed in Israel and already on the market, "we finally have activity in innovation in terms of new products coming in the pipeline," Luciano Rossetti, head of global research and development at Merck's biopharma business Merck Seronotold Reuters during a visit to Israel.
"The company is in a pretty critical time, with a late-stage pipeline in which there could be important filings and launches," he said.
Rossetti, who joined the company from U.S. drugmaker Merck & Co 15 months ago, said the innovation taking place at the German Merck was generating enthusiasm among its employees.
"We see people who want to work with us in R&D. This wasn't true a few years ago," he said.
Rebif, an established injectable MS drug, faces competition from a new generation of oral drugs. Rebif sales dropped a currency-adjusted 12 percent in the second quarter.
At the forefront of Merck's cancer pipeline is avelumab, a treatment that harnesses the power of the immune system, which it is developing with Pfizer. Bristol-Myers Squibb and Merck & Co already have already received approval for cancer immunotherapies, a field that is developing quickly.
Avelumab is in an advanced Phase 3 trial for the treatment of non-small cell lung cancer and has been fast-tracked by the U.S. Food and Drug Administration (FDA) for Merkel cell carcinoma, a rare form of skin cancer.
Merck expects the first commercial launch of the antibody in 2017 and is working towards at least one additional launch for different cancers every year through 2022.
Another cancer drug is evofosfamide, with data from two Phase III trials expected by year-end. Merck and its partner Threshold Pharmaceuticals may file for regulatory approval in mid-2016, with a 2017 launch possible to treat pancreatic cancer and soft tissue sarcoma.
"Even though we are mid-sized, our pipeline is very rich," Rossetti said, adding that the alliance with Pfizer will enable the companies to combine compounds with avelumab to treat various cancers.
"That is the strength of the alliance," he said. "We have more than enough critical mass in oncology."
The company is now in the stage of a rapid evolution considering the 80% focus on the oncology and immune-oncology drug business, as implied by the company spekesperson.
Rebif has taken a slow dip in the market as there is an increases competition from a new generation of oral drugs.
Amidst the growing participation from the company's workers in the R&D, the company is optimistic on its fortunes any time soon. At the forefront of the cancer research is the drug, avelumab , a treatment that harnesses the power of immune system.
In addition to Rebif and cancer drug Erbitux, which were partially developed in Israel and already on the market, "we finally have activity in innovation in terms of new products coming in the pipeline," Luciano Rossetti, head of global research and development at Merck's biopharma business Merck Seronotold Reuters during a visit to Israel.
"The company is in a pretty critical time, with a late-stage pipeline in which there could be important filings and launches," he said.
Rossetti, who joined the company from U.S. drugmaker Merck & Co 15 months ago, said the innovation taking place at the German Merck was generating enthusiasm among its employees.
"We see people who want to work with us in R&D. This wasn't true a few years ago," he said.
Rebif, an established injectable MS drug, faces competition from a new generation of oral drugs. Rebif sales dropped a currency-adjusted 12 percent in the second quarter.
At the forefront of Merck's cancer pipeline is avelumab, a treatment that harnesses the power of the immune system, which it is developing with Pfizer. Bristol-Myers Squibb and Merck & Co already have already received approval for cancer immunotherapies, a field that is developing quickly.
Avelumab is in an advanced Phase 3 trial for the treatment of non-small cell lung cancer and has been fast-tracked by the U.S. Food and Drug Administration (FDA) for Merkel cell carcinoma, a rare form of skin cancer.
Merck expects the first commercial launch of the antibody in 2017 and is working towards at least one additional launch for different cancers every year through 2022.
Another cancer drug is evofosfamide, with data from two Phase III trials expected by year-end. Merck and its partner Threshold Pharmaceuticals may file for regulatory approval in mid-2016, with a 2017 launch possible to treat pancreatic cancer and soft tissue sarcoma.
"Even though we are mid-sized, our pipeline is very rich," Rossetti said, adding that the alliance with Pfizer will enable the companies to combine compounds with avelumab to treat various cancers.
"That is the strength of the alliance," he said. "We have more than enough critical mass in oncology."
Our comments section is governed by our Comments Policy . By posting comments at Medical Dialogues you automatically agree with our Comments Policy , Terms And Conditions and Privacy Policy .
Disclaimer: This website is primarily for healthcare professionals. The content here does not replace medical advice and should not be used as medical, diagnostic, endorsement, treatment, or prescription advice. Medical science evolves rapidly, and we strive to keep our information current. If you find any discrepancies, please contact us at corrections@medicaldialogues.in. Read our Correction Policy here. Nothing here should be used as a substitute for medical advice, diagnosis, or treatment. We do not endorse any healthcare advice that contradicts a physician's guidance. Use of this site is subject to our Terms of Use, Privacy Policy, and Advertisement Policy. For more details, read our Full Disclaimer here.
NOTE: Join us in combating medical misinformation. If you encounter a questionable health, medical, or medical education claim, email us at factcheck@medicaldialogues.in for evaluation.