Molecular switch "Myb", which creates long term immunity discovered

"When our immune system encounters a new pathogen, it can create plasma cells that secrete antibodies to specifically prevent future infections, generating immunity," said Kim Good-Jacobson from the Walter and Eliza Hall Institute in Melbourne in a paper appeared in the Journal of Experimental Medicine.

The team discovered that when the gene that produces the protein called Myb was removed, plasma cells were no longer able to move into the bone marrow to provide long-term immunity.

"Myb is a type of protein called a transcription factor, which binds to DNA and, in effect, switches genes 'on' or 'off'," said Good-Jacobson.

If we can understand how to flip the molecular switch in plasma cells and activate Myb production, we might be able to encourage the immune system to create long-term immunity for a range of infections, authors noted.