Americans on dialysis more likely to develop CVD than their Japanese counterparts

During a median follow-up of five years, the CRIC participants had a significantly higher risk for CVD and death compared to the CKD-JAC participants. The differences in CRP and phosphate levels between the two cohorts partially mediated the difference in CVD risk, but echocardiographic parameters (LVMI and EF) were stronger mediators of the differences.

The study also suggests that differences in BMI, CRP, and phosphate levels may contribute to the higher risk of CVD in patients with predialysis CKD in the United States compared to Japan, but these differences are not the sole mediators of the observed differences in CVD risk. The findings of this study could inform the development of interventions to reduce CVD risk in patients with CKD.

Reference:

Imaizumi, T., Fujii, N., Hamano, T., Yang, W., Taguri, M., Kansal, M., Mehta, R., Shafi, T., Taliercio, J., Go, A., Rao, P., Hamm, L. L., Deo, R., Maruyama, S., Cohen, D. L., … Unruh, M. L. (2023). Excess risk of cardiovascular events in patients in the United States vs. Japan with chronic kidney disease is mediated mainly by left ventricular structure and function. In Kidney International. Elsevier BV. https://doi.org/10.1016/j.kint.2023.01.008