Anaemia in diabetes patients with or without CKD tied to significant risk of death
USA: The presence of anaemia, with or without chronic kidney disease (CKD), in diabetic patients is associated with two- to threefold increased mortality risk compared with adults having neither condition, says a recent study featured in Diabetes Research and Clinical Practice. The findings indicate that anaemia may strongly predict mortality in adults with diabetes.
There is a high prevalence of diabetes in the US, impacting about 11% of the adult population. Much focus has been placed on end-organ damage and major CVD (cardiovascular disease) events as diabetes complications. Still, it is also vital to understand comorbid conditions such as anaemia and their role in long-term prognosis. Anaemia affects about 8% and 18% of diabetic patients and increases the risk of complications such as diabetic foot ulcers, heart failure, and diabetic retinopathy.
Through multiple pathophysiological mechanisms, hyperglycemia significantly contributes to CKD onset and progression, itself a known risk factor for anaemia, increased mortality, and CVD comorbidity. Increased levels of circulating inflammatory cytokines in the hyperglycemic state can result in anaemia. Therefore, anaemia and chronic kidney disease may be significant markers of diabetes outcomes owing to their unique etiologies among adults with diabetes.
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