Anemia, AF and hyperuricemia identified as risk factors for new onset CKD: Study

Diabetes and cardiovascular diseases are most common causes of onset of kidney disease.

Various risk factors have been identified for the new onset or rapid deterioration of chronic kidney disease (CKD). A new study by Tomohiro Kaneko and team reported that other factors like anemia and hyperuricemia were identified as risk factors for new-onset CKD over a short period of time.

This study is published in Clinical Kidney Journal.

The objective of the study was to evaluate various risk factors that caused onset of chronic kidney disease.

The study was based on the results of specific annual health checkups at Tama City (n = 18 383) in 2017 and 2018, we analyzed the factors that cause new-onset CKD and the risk factors that rapidly worsen renal function. For new-onset CKD, proteinuria and estimated glomerular filtration rate (eGFR) <60 mL/min/1.73 m2 were examined separately. Rapid deterioration of renal function was defined as an eGFR ≥25% less than the previous year.

The results of the study were found to be

• Multivariate analysis showed that in addition to age and impaired glucose tolerance, anemia and atrial fibrillation (AF) were risk factors for the new appearance of proteinuria.

• Risk factors for a decrease in eGFR to <60 mL/min/1.73 m2 were age and hyperuricemia.

• Age, systolic hypertension, urinary protein and urinary occult blood, high triglycerides and anemia were significant risk factors for the rapid deterioration of renal function in patients with CKD Stage ≥3.

Kaneko and team concluded that "From the results of specific annual health checkups at Tama City, AF, anemia and hyperuricemia were identified as risk factors for new-onset CKD over a short period of 1 year. Anemia was also a factor for the rapid deterioration of kidney function in subjects with renal dysfunction."

Therefore treatment for anemia and AF may be useful in reducing the development and progression of CKD.

For further information: https://academic.oup.com/ckj/article/14/10/2221/6118195