Asymptomatic Nephrolithiasis tied to faster Kidney Function Decline in polycystic kidney disease: Study
Researchers have found in a new study that asymptomatic kidney stones are linked to a faster decline in kidney function in patients with autosomal dominant polycystic kidney disease (ADPKD). This emphasizes the need for regular monitoring and management of kidney stones, even when no symptoms are present, to help reduce their impact on renal health.
Autosomal Dominant Polycystic Kidney Disease (ADPKD) is a common hereditary disorder leading to end-stage kidney disease due to the progressive formation of renal cysts. Nephrolithiasis is a frequent complication of ADPKD, with a prevalence significantly higher than in the general population.
However, its role in disease progression remains underexplored. This study investigates the impact of asymptomatic nephrolithiasis on kidney function decline in ADPKD patients.
A retrospective cohort of 195 ADPKD patients was followed at our nephrology clinic. Of these, 85 patients had nephrolithiasis (N+), and 110 did not (N-). Data on demographic characteristics, biochemical parameters, and kidney function were collected. ΔeGFR (change in eGFR over time) served as the primary outcome. Statistical analyses, including correlation and multiple linear regression, were performed to assess the predictors of ΔeGFR.
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