Drug may reverse kidney damage caused by lupus

Craft and lead author Ping-Min Chen, a former graduate student at Yale now a postdoctoral researcher at Harvard Medical School, investigated the effects these invasive T cells had in lupus nephritis. They found that the T cells implicated in lupus express a factor called hypoxia-inducible factor-1 (HIF-1), which is regulated by oxygen levels in the kidney. When activated, HIF-1 instructs the T cells to attack tissues, further lowering tissue oxygen levels and causing more kidney damage.

The researchers theorized that blocking HIF-1 might help prevent oxygen depletion and damage of kidney tissue. They used a drug to inhibit HIF-1 -- which has been used in clinical trials as a treatment for cancer in humans -- to treat mice with models of lupus. They found the drug slowed infiltration of T cells into kidney tissue and reversed damage. They also found that the same HIF-1 regulated damage is present in biopsy samples of SLE patients with lupus nephritis.

"The findings suggest this therapy might be beneficial in lupus nephritis," Craft said. "Since this drug and others that block HIF-1 function have been used in humans with cancer, they could be used for treatment of patients with lupus."

For more details click on the link: DOI: 10.1126/scitranslmed.aay1620