Elevated Phosphorus tied with Primary Failure of Arteriovenous Fistulas: Study

Results of the study are as follows:

• They include 622 AVFs performed in 482 patients. 86.8% were autologous. 66.6% were male, with an average age of 65.4 ± 14 years.
• The most frequent CKD etiology were diabetic nephropathy (30.2%), unknown etiology (18%), and glomerular etiology (16.6%). 91.2% had high blood pressure (HBP) and 47.9% diabetes mellitus (DM). 48.7% received antiplatelet therapy and 15.6% anticoagulation prior to the creation of the AVF. 27% presented primary failure.
• The univariate analysis showed statistical significance for qualitative variables including HBP, statin treatment and antiplatelet therapy, and for quantitative variables including fibrinogen, serum phosphorus levels, C-reactive protein, triglycerides, ferritin and age.
• When performing a multivariate analysis using logistic regression, HBP, high serum phosphorus levels and statin treatment are predictors of vascular access thrombosis.

Thus, the researchers concluded that HBP and antiplatelet therapy prior to the creation of the vascular access behave as protective factors for primary failure. Elevated serum phosphorus levels are an independent factor for primary failure of AVFs.

Reference:

Pos-567 mineral bone disease associated with chronic kidney disease. Does it influence in primary permeability after the creation of vascular access for hemodialysis? By P. Castro Fernandez et al published in the Kidney International Reports.

DOI :https://doi.org/10.1016/j.ekir.2021.03.596