Erythropoietin Resistance Index helps predict mortality in CKD patients

Multivariate logistic regression analyses uncovered several factors negatively associated with high ERI baseline including dialysis vintage, white blood cell count, use of high flux dialyzer, body mass index, gender, and albumin levels by underscoring the complexity of ERI dynamics.

During the follow-up period, 13.9% of the subjects, including 89 deaths attributed to cardiac/vascular causes, were reported. Cox regression analysis further demonstrated a positive association between ERI and all-cause mortality, particularly in specific subgroups.

The findings underscore the significance of monitoring ERI levels by indicating a potential avenue for predicting mortality risk in MHD patients. This insight could prompt a potential shift in patient care with the need for increased attention and tailored interventions for those with elevated ERI. The findings of this study brings us one step closer to personalized healthcare strategies by equipping medical community with tools to anticipate and mitigate risks for their patients battling chronic kidney disease.

Source:

Zhao, X., Gan, L., Hou, F. F., Liang, X., Chen, X., Chen, Y., Ni, Z., & Zuo, L. (2024). The influencing factors of the erythropoietin resistance index and its association with all-cause mortality in maintenance hemodialysis patients. Renal Failure, 46(1). https://doi.org/10.1080/0886022x.2023.2290922