Finerenone and dapagliflozin combo significantly reduced albuminuria in non-diabetic CKD patients: Study
The effectiveness of dapagliflozin and finerenone in reducing albuminuria and slowing the progression of chronic kidney disease (CKD) has been established, but their additive effects have yet to be studied.
According to a study published in the Clinical Kidney Journal, Combining finerenone and dapagliflozin reduced albuminuria safely. Their combined effect was at least equal to each drug's effect alone, suggesting an additive effect.
The present study aimed to compare these two medications' individual and combined efficacy and safety in patients with non-diabetic CKD.
In a randomized, open-label clinical trial, researchers enrolled patients aged 18-80. These patients were on the maximum tolerated dose of an ACE inhibitor or angiotensin receptor blocker and had an eGFR of 25-45 mL/min/1,73 m[2] and albuminuria ranging from 150-2000 mg/g. The participants were assigned to receive either finerenone 20 mg/day or dapagliflozin 10 mg/day for a duration of four weeks, followed by a combination therapy for four weeks. Data were collected at the beginning of the study and weeks 4 and 8.
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