Gene polymorphisms linked to development of recurrent urolithiasis

Urolithiasis is one of the most prevalent diseases worldwide. Its prevalence is rising, both in developing and developed countries. Currently, the incidence and prevalence of urolithiasis is on the rise worldwide. Approximately 12% population of the world was affected by urolithiasis regardless of age, race, or sex.

It is known that genetic factors play big roles in the development of urolithiasis. One of the suspected factors is gene polymorphism. This study aims to find an accurate estimate of the association between genetic polymorphism and the risk of recurrent urolithiasis.

A systematic review and meta-analysis were performed on 12 studies from 3 databases that investigated gene polymorphism as an risk factor of urolithiasis. The review was done using Review Manager® version 5.3.The study was conducted through a comprehensive search from Medline/PubMed, Scopus, and Cochrane electronic databases for studies published between January 2000 and June 2023.

Results

Insignificant heterogenicity was found in this study. Populations from Asia and the Middle East are more likely to experience recurrent urolithiasis. Additionally, variation in the VDR and urokinase genes, particularly in the Asian population, increases the risk of developing recurrent urolithiasis.

The researchers found that Gene polymorphisms have significant roles in the development of urolithiasis, especially in the Middle Eastern region.Additionally, both VDR and urokinase gene polymorphism contributes to the susceptibility of recurrent urolithiasis particularly for the Asian population in the latter. Studies with a variety of population characteristics are recommended to be performed to further support our results.

Reference:

Rasyid, N., Soedarman, S. Genes polymorphism as risk factor of recurrent urolithiasis: a systematic review and meta-analysis. BMC Nephrol 24, 363 (2023). https://doi.org/10.1186/s12882-023-03368-y

Keywords:

Gene, polymorphisms, linked, development, urolithiasis, BMC Nephrology, Rasyid, N., Soedarman, S