Glomerular Hyperfiltration Raises Cardiovascular Risk in Type 2 Diabetes, Study Recommends Early Screening
South Korea: A study of over 1.9 million patients with type 2 diabetes (T2D) found that glomerular hyperfiltration (GHF) was associated with an increased risk of cardiovascular disease (CVD), particularly myocardial infarction (HR = 1.06) and heart failure (HR = 1.17).
"Patients with GHF (eGFR above the 95th percentile) had a 13% higher risk of CVD compared to those with moderate kidney function (eGFR between the 40th and 60th percentiles). GHF had the most significant impact on patients under 40 years of age," the researchers reported in the Clinical Journal of the American Society of Nephrology.
Seung Min Chung, Division of Endocrinology and Metabolism, Department of Internal Medicine, Yeungnam University College of Medicine, Daegu, Republic of Korea, and colleagues aimed to explore the effects of glomerular hyperfiltration on cardiovascular disease risk in patients with type 2 diabetes mellitus (T2DM).
For this purpose, the researchers conducted a retrospective cohort study using data from 1,952,053 patients with type 2 diabetes mellitus, sourced from the Korean National Health Insurance Service database between 2015 and 2016. Based on age- and sex-specific estimated glomerular filtration rate (eGFR) percentiles, patients were classified into five groups: <5 (low filtration), 5–40, 40–60, 60–95, and >95 (GHF). The study followed patients with incident cardiovascular disease (CVD), including myocardial infarction (MI), stroke, and hospitalization for heart failure (HF), until December 2022.
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