Higher serum Lipoprotein A level independent risk factor for mildly reduced eGFR
Chronic kidney disease (CKD) is a prevalent global health issue, affecting 10% of the adult population worldwide, with a 29.3% increase in prevalence from 1990 to 2017. This condition is associated with an increased risk of mortality and cardiovascular disease (CVD). Early identification and prevention of CKD are crucial.
Hong Zhang et al., in a recent study published in BMC Nephrology, have found that higher Lp(a) levels in Chinese people (middle-aged and elderly) have an association with an increased risk of mildly reduced eGFR, revealing the importance of evaluating and managing Lp(a) for early renal dysfunction detection.
One thousand sixty-four participants aged 40 years or older from Yonghong Community, China, were enrolled.eGFR levels between 60 and 90 mL/min/1.73m2 were considered mildly reduced eGFR. Lipoprotein (a) and eGFR data were collected through standardized questionnaires and biochemical measurements. The lipoprotein(a) concentration was determined using the latex-enhanced immunoturbidimetric test.
Key findings of this study are:
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