Iron Deficiency Linked to Kidney Failure, Mortality, and Heart Failure in CKD patients: Study
A new study has demonstrated that iron deficiency (ID) is significantly associated with an increased risk of kidney failure, all-cause mortality, and heart failure, regardless of the presence of anemia.
Iron deficiency (ID) is common in patients with chronic kidney disease (CKD) but remains underdiagnosed and its prognosis poorly documented in the absence of anemia. The study aimed to assess the relationship between ID and the risk of major adverse outcomes in patients with CKD. Using data from the French Chronic Kidney Disease - Renal Epidemiology and Information Network (CKD-REIN) cohort which included and followed over five years, 3,033 patients with CKD stages 2 to 5 CKD, we estimated the prevalence of ID, defined by a ferritin level < 100 μg/L and/or a transferrin saturation < 20%, and associated hazard ratios (HR) of kidney failure with replacement therapy, kidney failure defined by an eGFR < 15 mL/min per 1.73 m2 or initiation of kidney replacement therapy, all-cause mortality, and death or hospitalization for heart failure. Results: Baseline prevalence of ID in the cohort (66% men; mean age 67 ± 13 years) was 50% (48-52). Mean hemoglobin was 13 ± 1.7 g/dL, and only 31% of patients with ID also had a hemoglobin < 12 g/dL. In 2,803 patients with CKD stages 2-4 at baseline, ID was associated with a significantly increased risk of kidney failure, and of kidney failure with replacement therapy, with HRs adjusted for confounders and hemoglobin level of 1.22 (1.03-1.45) and 1.57 (1.27-1.94), respectively. Adjusted HRs for all-cause mortality and hospitalization or death for heart failure, were 1.31 (1.04-1.66) and 1.38 (1.07-1.80), respectively. This study shows that ID is significantly associated with the risk for kidney failure, all-cause mortality, and heart failure, independent of the presence of anaemia.
Reference:
Choukroun, Gabriel, et al. "Association Between Iron Deficiency and Risk of Major Events in Chronic Kidney Disease." Nephrologie & Therapeutique, vol. 20, no. 6, 2024, pp. 553-563.
Keywords:
Iron, Deficiency, Linked, Kidney, Failure, Mortality, Heart, Failure, CKD patients, Study, Choukroun, Gabriel
Disclaimer: This website is primarily for healthcare professionals. The content here does not replace medical advice and should not be used as medical, diagnostic, endorsement, treatment, or prescription advice. Medical science evolves rapidly, and we strive to keep our information current. If you find any discrepancies, please contact us at corrections@medicaldialogues.in. Read our Correction Policy here. Nothing here should be used as a substitute for medical advice, diagnosis, or treatment. We do not endorse any healthcare advice that contradicts a physician's guidance. Use of this site is subject to our Terms of Use, Privacy Policy, and Advertisement Policy. For more details, read our Full Disclaimer here.
NOTE: Join us in combating medical misinformation. If you encounter a questionable health, medical, or medical education claim, email us at factcheck@medicaldialogues.in for evaluation.