Kidney Dysfunction and Damage independently associated with increased risks of recurrent stroke and Death

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During the median follow-up of 4.3 years, the study concluded with the following clinical findings:

1. 1.The study found that 2481 patients had recurrent strokes and 4032 patients died.
2. 2.Chronic kidney disease was independently associated with increased risks of stroke recurrence and all-cause death even after adjusting for multiple confounding factors, including traditional cardiovascular risk factors.
3. 3.Both estimated glomerular filtration rate and proteinuria were independently associated with increased risks of stroke recurrence and death.
4. 4.Subgroup analysis revealed effect changes in the link of proteinuria with death based on age and stroke subtype.

The study's findings highlight the importance of identifying and managing kidney dysfunction and damage in patients with ischemic stroke to reduce the risks of recurrent stroke and all-cause death.

Dr. Kana Ueki, lead author of the study added that “Proteinuria was associated with an increased risk of death in older patients and those with certain stroke subtypes, suggesting the need for targeted interventions in these patient groups. Further studies are needed to investigate the underlying mechanisms linking kidney dysfunction and damage with stroke recurrence and death, as well as to evaluate the effectiveness of interventions.”

Reference:

Ueki K., Matsuo R., Kuwashiro T., Irie F., Wakisaka Y., Ago T., Kamouchi M., Kitazono T.; Decreased Estimated Glomerular Filtration Rate and Proteinuria and Long-Term Outcomes After Ischemic Stroke: A Longitudinal Observational Cohort Study, STROKE: AHA 2023.04.06 doi: https://doi.org/10.1161/STROKEAHA.122.040958