Low Serum Uromodulin Levels Linked to Diabetic Kidney Disease, finds study
Researchers have discovered a significant association of low serum levels of uromodulin with diabetic kidney disease (DKD), meaning it could be a predictive marker for the disease. A recent study was published in the journal of BMC Nephrology conducted by Shaimaa and colleagues.
This meta-analysis was based on the PRISMA protocol; systematically reviewed data from PubMed, Cochrane Library, Web of Science, and Scopus; and consisted of six studies which met the inclusion criteria by examining the relationship between serum uromodulin levels and DKD. The standardized mean difference (SMD) with a 95% confidence interval (CI) was applied to evaluate the association. Heterogeneity was determined using the I² statistic with a threshold of 50% for significant heterogeneity. Sensitivity and subgroup analyses were performed to explore the sources of heterogeneity, and quality of studies was evaluated using the Newcastle-Ottawa Scale (NOS). Publication bias was assessed by funnel plots and Egger's test.
In total, 1,774 patients were included in the meta-analysis. Pooled results are presented below:
Low Levels of Uromodulin: Serum uromodulin levels were found to be significantly lower in patients with DKD (SMD: -0.31; 95% CI: -0.48 to -0.13; I² = 45%).
Sensitivity Analysis: After sensitivity, results were still significant, and the heterogeneity was lost due to adjustment (SMD:-0.38; 95% CI:-0.49 to -0.27; I²=3%).
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