Lowering BP may halt kidney function decline in CKD patients
Sweden: Lower clinic office BP is associated with more favorable kidney outcomes in people with an estimated glomerular filtration rate (eGFR) of less than 30 ml/min per 1.73 m2, states study results published in the Journal of Hypertension.
Globally, an estimated 26% of the world's population (972 million people) has hypertension and the prevalence is expected to increase further. Hypertension is a leading risk factor for mortality and morbidity, along with chronic kidney disease (CKD) and various others. CKD and hypertension are closely associated with an overlapping and intermingled cause and effect relationship. Older randomized controlled trials (RCT) and observational data have indicated that higher BP is a risk factor for the progression of CKD, especially in patients with albuminuria.
The co-author Al-Sodany, Karolinska Institutet, Sweden, and his team investigated blood pressure and its association with kidney outcomes in patients with nondialysis CKD stage 4–5 (eGFR <30 ml/min per 1.73 m2) and different levels of albuminuria, using a nationwide, contemporary cohort under nephrology care.
Investigators enrolled a total of 18 071 CKD stage 4–5 patients from routine nephrology care (2010–2017). Multivariable adjusted joint models were used to explore the association between both baseline and repeated clinic office BP and eGFR slope and kidney replacement therapy (KRT). The analyses were stratified on albuminuria at baseline.
Disclaimer: This website is primarily for healthcare professionals. The content here does not replace medical advice and should not be used as medical, diagnostic, endorsement, treatment, or prescription advice. Medical science evolves rapidly, and we strive to keep our information current. If you find any discrepancies, please contact us at corrections@medicaldialogues.in. Read our Correction Policy here. Nothing here should be used as a substitute for medical advice, diagnosis, or treatment. We do not endorse any healthcare advice that contradicts a physician's guidance. Use of this site is subject to our Terms of Use, Privacy Policy, and Advertisement Policy. For more details, read our Full Disclaimer here.
NOTE: Join us in combating medical misinformation. If you encounter a questionable health, medical, or medical education claim, email us at factcheck@medicaldialogues.in for evaluation.