Niacin intake linked to lower mortality among patients with CKD, finds study
Researchers have found in a new research that higher dietary niacin intake was associated with lower all-cause mortality risk in patients with chronic kidney disease.
Autosomal Dominant Polycystic Kidney Disease (ADPKD) is a common hereditary disorder leading to end-stage kidney disease due to the progressive formation of renal cysts. Nephrolithiasis is a frequent complication of ADPKD, with a prevalence significantly higher than in the general population. However, its role in disease progression remains underexplored.
This study investigates the impact of asymptomatic nephrolithiasis on kidney function decline in ADPKD patients. A retrospective cohort of 195 ADPKD patients was followed at our nephrology clinic. Of these, 85 patients had nephrolithiasis (N+), and 110 did not (N-). Data on demographic characteristics, biochemical parameters, and kidney function were collected. ΔeGFR (change in eGFR over time) served as the primary outcome. Statistical analyses, including correlation and multiple linear regression, were performed to assess the predictors of ΔeGFR.
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