No significant association between depression and CKD progression: Study
No significant association was found between depressive symptoms and a higher hazard of dialysis initiation or combined outcome in patients with chronic kidney disease, according to a recent study published in the Clinical Kidney Journal.
Depressive symptoms are associated with adverse clinical outcomes in patients with end-stage kidney disease. Yet, few small studies have examined this association in patients with earlier phases of chronic kidney disease (CKD). We studied associations between baseline depressive symptoms and clinical outcomes in older patients with advanced CKD and examined whether these associations differed depending on sex.
CKD patients (≥65 years; eGFR ≤ 20 mL/min/1.73m2) were included from a European multicenter prospective cohort between 2012 and 2019. Depressive symptoms were measured by the 5-item Mental Health Inventory (cut-off ≤ 70;0–100 scale). Cox proportional hazard analysis was used to study associations between depressive symptoms and time to dialysis initiation, all-cause mortality, and these outcomes combined. A joint model was used to study the association between depressive symptoms and kidney function over time. Analyses were adjusted for potential baseline confounders.
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