Progress in Kidney Transplants: Therapeutic Hypothermia Emerges as Solution for Delayed Graft Function in new research
In a comprehensive multicenter randomized clinical trial, researchers have explored the effectiveness of therapeutic hypothermia in preventing delayed graft function in kidney transplants from low-risk, non-pumped donors after brain death. The study, spanning from August 10, 2017, to May 21, 2020, across four Organ Procurement Organizations in the United States, aimed to address a crucial question in transplantation medicine. The study's findings indicate that, in low-risk, non-pumped kidneys from brain-dead donors, therapeutic hypothermia does not appear to significantly prevent delayed graft function in kidney transplant recipients.
The study results were published in the journal JAMA Network Open.
The occurrence of delayed graft function in recipients of kidney transplants is linked to heightened financial expenses and additional burdens on patients. Notably, in donors exhibiting a high Kidney Donor Profile Index, whose kidneys do not undergo machine perfusion, therapeutic hypothermia has demonstrated its efficacy in providing a protective advantage against the development of delayed graft function. The primary objective was to determine whether maintaining donors at a lower temperature (34.0-35.0 °C) through therapeutic hypothermia was superior to normothermia (36.5-37.5 °C) in preventing delayed graft function.
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