Slow walking pace and weight gain associated with CKD risk among adults with obesity

Key results of this study are:

• This study had 1208 included MESA participants with a median BMI of 33.0 kg/m2.
• Out of these participants, 15% developed CKD.
• There was an association between slow walking pace and eGFR decline and CKD risk with aHR 1.48.
• Weight gain increased CKD risk with aHR 1.34.
• There was no significant interaction by baseline hypertension status.

The slow walking pace and weight gain were associated with an increased risk of chronic kidney disease (CKD) in adults with Obesity, they said.

"Weight gain can cause direct strain on kidney function and increase risks of hypertension and diabetes, which are leading causes of chronic kidney disease,” says lead study author Meera Nair Harhay, MD, MPH, a professor at Drexel University College of Medicine in Philadelphia and nephrologist at the University of Pennsylvania Transplant Institute.

This study suggests that maintaining a healthy weight and engaging in regular physical activity may help reduce the risk of chronic kidney disease (CKD).

Reference:

Harhay, M. N., Kim, Y., Moore, K., Harhay, M. O., Katz, R., Shlipak, M. G., & Mattix-Kramer, H. (2023). Modifiable kidney disease risk factors among nondiabetic adults with Obesity from the Multi‐Ethnic Study of Atherosclerosis. Obesity. https://doi.org/10.1002/oby.23883