Stress Hyperglycemia Ratio Identified as Reliable Predictor of AKI in CKD Patients: Study

A new study published in the journal BMC Nephrology revealed that Stress Hyperglycemia Ratio (SHR) is a dependable and independent marker for predicting the risk of acute kidney injury (AKI) and poor renal outcomes in patients with chronic kidney disease (CKD).

Among hospitalized patients, AKI is a common severe condition that carries a significant risk of death. It includes several causes, intricate processes, a high incidence, high death rates, and severe negative outcomes. Individuals who have AKI are 2.67 times more likely to develop or progress to chronic kidney disease, 4.81 times more likely to experience uremia, 38% more likely to experience cardiovascular (CV) events, 1.80 times more likely to die, and 32.4% more likely to readmit within 5 years.

An independent predictor of worse outcomes in critically sick patients is stress hyperglycemia (SH), a transient increase in blood sugar brought on by physiological or psychological stress. However, persistent hyperglycemia can influence fasting blood glucose (FBG) values, making it more difficult to differentiate them from acute hyperglycemia.

The stress hyperglycemia ratio has been proposed as a more accurate way to detect patients' real blood glucose levels. Diabetes mellitus (DM) does not affect SHR, which can measure the severity of SH by reflecting the pace at which fasting glucose levels fluctuate during stress. This study was set to investigate the relationship between SHR and the risk of AKI and mortality in people with chronic kidney disease.