Study Finds Significant Link Between Serum Magnesium Levels and Carotid Atherosclerosis in hemodialysis patients

The mean CIMT of these patients was measured and recorded by doppler ultrasonography. Patients were divided into two groups according to their serum magnesium level. Correlation analysis and linear regression analysis were used to define the relationship between study parameters.

We divided our patients into 2 groups according to Mg value as group 1 (Mg ≥ 2.3 mg/dl) and group 2 (Mg < 2.3 mg/dl).

Results: The mean CIMT of patients with group 1 and group 2 were respectively 0.93 ± 0.22 mm and 1.03 ± 0.22 mm. There was statistically significant difference between two groups in terms of the mean CIMT value (p = 0.045). We found negative, low-level, statistically significant correlations between Mg and mean CIMT ​​(r=-0.272; p = 0.010), calcium and mean CIMT (r: -0.221, p: 0.039) and hemoglobin and mean CIMT (r: -0.215, p: 0.044).

According to regression analysis, serum magnesium level and age were found independent risk factors for mean CIMT value (p: 0.004 and p: 0.045). They found a significant relationship between serum Mg level and CIMT, which indicates carotid atherosclerosis.

Reference:

Kara, A.V., Ozdemir, R., Inan, H. et al. Effect of serum magnesium level on carotid intima media thickness in hemodialysis patients. BMC Nephrol 26, 270 (2025). https://doi.org/10.1186/s12882-025-04168-2