Urinary creatinine Promising Biomarker for Early Detection of DKD in T2DM Patients: Study

Medically Reviewed By : Dr. Kamal Kant Kohli

Published On 2025-02-12 14:30 GMT | Update On 2025-02-13 06:37 GMT

This study aims to investigate the relationship between urinary creatinine (UCr) and the risk and severity of Diabetic Kidney Disease (DKD) in patients with Type 2 Diabetes Mellitus (T2DM). The goal is to establish UCr as a potential biomarker for early Diabetic Kidney Disease detection and severity assessment.

A retrospective cross-sectional analysis was conducted using medical records of Type 2 Diabetes Mellitus patients. Patients were classified with and without Diabetic Kidney Disease, and relevant clinical data, including demographic, blood, and urine parameters, were collected. Logistic regression and receiver operating characteristic (ROC) curve analysis evaluated the association between UCr levels and Diabetic Kidney Disease.

Curve fitting and threshold effect model were used to further evaluate the relationship between UCr and the incidence and severity of Diabetic Kidney Disease. Results: A total of 302 Type 2 Diabetes Mellitus patients were analyzed, with 137 diagnosed with Diabetic Kidney Disease. Significant differences in clinical parameters were observed between the Diabetic Kidney Disease and non-diabetic Kidney Disease groups, particularly in UCr, urine albumin levels, and eGFR. UCr levels demonstrated a strong association with Diabetic Kidney Disease.

Moreover, a non-linear relationship was identified, with specific inflection points indicating different correlation patterns of UCr with Diabetic Kidney Disease occurrence and progression. The findings of this study highlight the potential of UCr as a valuable biomarker for early detection and assessment of Diabetic Kidney Disease in Type 2 Diabetes Mellitus patients. Incorporating UCr measurements into routine clinical practice could enhance the early identification of patients at risk for kidney complications, leading to timely intervention and improved patient outcomes.

Reference:

Cao, H., Song, L., Wang, X. et al. Non-linear relationship between urinary creatinine and diabetic kidney disease: implications for clinical practice. BMC Nephrol 26, 40 (2025). https://doi.org/10.1186/s12882-025-03971-1

Article Source : BMC Nephrology

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Dr. Shravani Dali

Dr. Shravani Dali has completed her BDS from Pravara institute of medical sciences, loni. Following which she extensively worked in the healthcare sector for 2+ years. She has been actively involved in writing blogs in field of health and wellness. Currently she is pursuing her Masters of public health-health administration from Tata institute of social sciences. She can be contacted at editorial@medicaldialogues.in.

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Urinary creatinine Promising Biomarker for Early Detection of DKD in T2DM Patients: Study

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