Urinary creatinine Promising Biomarker for Early Detection of DKD in T2DM Patients: Study

Medically Reviewed By : Dr. Kamal Kant Kohli

Published On 2025-02-12 14:30 GMT | Update On 2025-02-13 06:37 GMT

This study aims to investigate the relationship between urinary creatinine (UCr) and the risk and severity of Diabetic Kidney Disease (DKD) in patients with Type 2 Diabetes Mellitus (T2DM). The goal is to establish UCr as a potential biomarker for early Diabetic Kidney Disease detection and severity assessment.

A retrospective cross-sectional analysis was conducted using medical records of Type 2 Diabetes Mellitus patients. Patients were classified with and without Diabetic Kidney Disease, and relevant clinical data, including demographic, blood, and urine parameters, were collected. Logistic regression and receiver operating characteristic (ROC) curve analysis evaluated the association between UCr levels and Diabetic Kidney Disease.

Curve fitting and threshold effect model were used to further evaluate the relationship between UCr and the incidence and severity of Diabetic Kidney Disease. Results: A total of 302 Type 2 Diabetes Mellitus patients were analyzed, with 137 diagnosed with Diabetic Kidney Disease. Significant differences in clinical parameters were observed between the Diabetic Kidney Disease and non-diabetic Kidney Disease groups, particularly in UCr, urine albumin levels, and eGFR. UCr levels demonstrated a strong association with Diabetic Kidney Disease.

Moreover, a non-linear relationship was identified, with specific inflection points indicating different correlation patterns of UCr with Diabetic Kidney Disease occurrence and progression. The findings of this study highlight the potential of UCr as a valuable biomarker for early detection and assessment of Diabetic Kidney Disease in Type 2 Diabetes Mellitus patients. Incorporating UCr measurements into routine clinical practice could enhance the early identification of patients at risk for kidney complications, leading to timely intervention and improved patient outcomes.

Reference:

Cao, H., Song, L., Wang, X. et al. Non-linear relationship between urinary creatinine and diabetic kidney disease: implications for clinical practice. BMC Nephrol 26, 40 (2025). https://doi.org/10.1186/s12882-025-03971-1

Article Source : BMC Nephrology

Disclaimer: This website is primarily for healthcare professionals. The content here does not replace medical advice and should not be used as medical, diagnostic, endorsement, treatment, or prescription advice. Medical science evolves rapidly, and we strive to keep our information current. If you find any discrepancies, please contact us at corrections@medicaldialogues.in. Read our Correction Policy here. Nothing here should be used as a substitute for medical advice, diagnosis, or treatment. We do not endorse any healthcare advice that contradicts a physician's guidance. Use of this site is subject to our Terms of Use, Privacy Policy, and Advertisement Policy. For more details, read our Full Disclaimer here.

NOTE: Join us in combating medical misinformation. If you encounter a questionable health, medical, or medical education claim, email us at factcheck@medicaldialogues.in for evaluation.

Dr. Shravani Dali

Dr. Shravani Dali has completed her BDS from Pravara institute of medical sciences, loni. Following which she extensively worked in the healthcare sector for 2+ years. She has been actively involved in writing blogs in field of health and wellness. Currently she is pursuing her Masters of public health-health administration from Tata institute of social sciences. She can be contacted at editorial@medicaldialogues.in.

Comments Policy

Our comments section is governed by our Comments Policy . By posting comments at Medical Dialogues you automatically agree with our Comments Policy , Terms And Conditions and Privacy Policy .

Urinary creatinine Promising Biomarker for Early Detection of DKD in T2DM Patients: Study

Similar News

High UBUR Independent Predictor of Proteinuria Remission in Nephrotic Syndrome, suggests study

Women with Genetic Predisposition to Depression More Likely to Experience Nocturia and Incontinence: Study Suggests

U-Shaped Link Observed Between Uric Acid and Heart Risks in Children with Kidney Disease: Study

Comparable Cardiorenal Outcomes Among Three GLP-1 Receptor Agonists in Veterans with Type 2 Diabetes: JAMA

Necrotising enterocolitis Significantly Increases Risk of Acute Kidney Injury in Preterm Infants, reveals research

Vitamin C Deficiency Common in Patients with Chronic Kidney Disease: Study

Higher Protein Intake After Kidney Transplant Improves Graft Function and Metabolism: Study

Dotinurad Outperforms Febuxostat in Lowering Uric Acid Levels in Chinese Gout Patients: Phase 3 Trial