Vitamin D might reduce risk of nephropathy in diabetes patients
Vitamin D is associated with reduced risk of diabetic nephropathy in diabetics suggests a new study published in the BMC Nephrology. However, whether this association is causative is uncertain.Diabetic nephropathy (DN) is the leading cause of end-stage renal disease (ESRD) and is associated with a high risk of cardiovascular disease. Proteinuria, hypertension, and gradual declines in...
Vitamin D is associated with reduced risk of diabetic nephropathy in diabetics suggests a new study published in the BMC Nephrology. However, whether this association is causative is uncertain.
Diabetic nephropathy (DN) is the leading cause of end-stage renal disease (ESRD) and is associated with a high risk of cardiovascular disease. Proteinuria, hypertension, and gradual declines in kidney function are the clinical manifestations
Results of the MR analysis showed that there was no causal association between 25(OH)D with the early/later stage of T1DN (early: OR = 0.903, 95%CI: 0.229 to 3.555; later: OR = 1.213, 95%CI: 0.367 to 4.010) and T2DN (early: OR = 0.588, 95%CI: 0.182 to 1.904; later: OR = 0.904, 95%CI: 0.376 to 2.173), nor with the kidney function of patients with diabetes mellitus: eGFRcyea (creatinine-based estimated GFR) (Beta = 0.007, 95%CI: -0.355 to 0.369)) or UACR (urinary albumin creatinine ratio) (Beta = 0.186, 95%CI: -0.961 to 1.333)).
He, M., Yang, T., Zhou, P. et al. A Mendelian randomization study on causal effects of 25(OH) vitamin D levels on diabetic nephropathy. BMC Nephrol 24, 192 (2023). https://doi.org/10.1186/s12882-023-03186-2
Keywords:
He, M., Yang, T., Zhou, P, Mendelian, randomization, study, causal, effects, 25(OH), vitamin, D, levels, diabetic, nephropathy, BMC Nephrology
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