Ziltivekimab targets IL-6 to effectively treat anemia patients with CKD stage 3-5, finds study
Anemia affects about 15% of CKD patients and is linked to increased morbidity, mortality, and reduced quality of life. In 30-50% of dialysis patients with kidney failure, high biomarkers of inflammation such as IL-6 and hsCRP are present. Elevated hsCRP (high-sensitivity C-reactive protein) levels are also associated with anemia onset in early CKD stages. Reducing inflammation (indicated by hsCRP decline) may improve CKD patient outcomes.
Pablo E Pergola et al. and colleagues, in a recent study published in the Journal of the American Society of Nephrology, said that Anti-inflammatory therapy with ziltivekimab improved anaemia and iron homeostasis markers in stage 3-5 CKD patients with systemic inflammation, suggesting a possible role in anaemia management.
In the phase 2 RESCUE trial, ziltivekimab reduced inflammation biomarkers compared to placebo in CKD patients with systemic inflammation (hs-CRP ≥2 mg/L). This subanalysis assessed ziltivekimab's effect on Hb and iron homeostasis in these patients.
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