Add on batoclimab tied to sustained improvement in activities of Daily Living score in Myasthenia Gravis : JAMA

Written By : Aditi

Medically Reviewed By : Dr. Kamal Kant Kohli

Published On 2024-03-06 14:00 GMT | Update On 2024-03-06 14:01 GMT

MG is caused by autoantibodies disrupting the neuromuscular junction. The neonatal fragment crystallizable receptor (FcRn) antagonists, efgartigimod and rozanolixizumab, reduce circulating immunoglobulin G (IgG) levels and alleviate symptoms in generalized MG cases.

A recent study found that batoclimab led to a sustained improvement in the Myasthenia Gravis Activities of Daily Living score compared to the placebo group. No severe side effects were reported. This suggests that batoclimab, an FcRn inhibitor, could be an important addition to the limited treatments available for Myasthenia gravis (MG).

This original investigation was published in JAMA Neurology.

The clinical trial was conducted at 27 centres in China from September 15, 2021, to June 29, 2022. It enrolled adult patients who tested positive for antibodies. These patients received either batoclimab or a placebo in addition to standard treatment. Each cycle consisted of six weekly subcutaneous injections of batoclimab or placebo, followed by four weeks of observation. A second cycle was given to those who required ongoing treatment. The primary outcome was a 3-point or greater improvement in the Myasthenia Gravis Activities of Daily Living (MG-ADL) score for at least four consecutive weeks in individuals with antibodies to acetylcholine receptors or muscle-specific kinase.

Key findings from the study are:

• The study population included 43 men and 88 women, the mean age being 43, with a history of generalized myasthenia gravis.

• The study was carried out in 27 hospitals in China.

• The rate of sustained MG-ADL improvement in the first cycle in antibody-positive patients in the placebo and batoclimab groups was 31.3% (20/ 64) and 58.2% (39/ 67), respectively, with an odds ratio of 3.45.

• The MG-ADL score diverged between the two groups as early as week 2.

• The rates of treatment-related and severe treatment-emergent adverse events in patients were 36.9% and 7.7% in the placebo group vs 70.1% and 3.0% in the batoclimab group, respectively.

Study strengths include a more significant number of participating centres and a broad representation of the overall generalized MG patient population.

Study limitations include limited treatment cycles, lack of data on long-term safety, and enrolment of only one patient with negative AChR/MuSK antibodies.

Concluding further, batoclimab resulted in a higher rate of sustained MG-ADL improvement in adult patients with generalized MG than placebo.

Reference:

Yan C, Yue Y, Guan Y, et al. Batoclimab vs Placebo for Generalized Myasthenia Gravis: A Randomized Clinical Trial. JAMA Neurol. Published online March 04, 2024. doi:10.1001/jamaneurol.2024.0044

Article Source : JAMA Neurology.

Disclaimer: This website is primarily for healthcare professionals. The content here does not replace medical advice and should not be used as medical, diagnostic, endorsement, treatment, or prescription advice. Medical science evolves rapidly, and we strive to keep our information current. If you find any discrepancies, please contact us at corrections@medicaldialogues.in. Read our Correction Policy here. Nothing here should be used as a substitute for medical advice, diagnosis, or treatment. We do not endorse any healthcare advice that contradicts a physician's guidance. Use of this site is subject to our Terms of Use, Privacy Policy, and Advertisement Policy. For more details, read our Full Disclaimer here.

NOTE: Join us in combating medical misinformation. If you encounter a questionable health, medical, or medical education claim, email us at factcheck@medicaldialogues.in for evaluation.

Aditi

Dr. Aditi Yadav is a BDS, MDS in Periodontics and Implantology. She has a clinical experience of 5 years as a laser dental surgeon. She also has a Diploma in clinical research and pharmacovigilance and is a Certified data scientist. She is currently working as a content developer in e-health services. Dr. Yadav has a keen interest in Medical Journalism and is actively involved in Medical Research writing.

Comments Policy

Our comments section is governed by our Comments Policy . By posting comments at Medical Dialogues you automatically agree with our Comments Policy , Terms And Conditions and Privacy Policy .

Indian Review Stresses Prevention Strategies, Early Referral, and Timely Liver Transplantation in Pediatric Acute Liver Failure

2025-08-01 02:30 GMT

Add on batoclimab tied to sustained improvement in activities of Daily Living score in Myasthenia Gravis : JAMA

Similar News

UTIs Linked to Short-Term Increased Risk of Heart Attack and Stroke, reveals research

Semaglutide and Liraglutide linked to Elevated Risk of Optic Nerve Damage in Seniors With Type 2 Diabetes: JAMA

Vitamin B1 Shows Promise in Preventing Alcohol-Related Headaches: Study

Study highlights the severity of acute necrotizing encephalopathy in kids with the flu: Study

Indian Review Stresses Prevention Strategies, Early Referral, and Timely Liver Transplantation in Pediatric Acute Liver Failure

PET imaging links brain inflammation to speech disorder and Parkinson-like syndrome: Study

Gene Therapy Outperforms Cochlear Implants in Hearing and Speech Outcomes for Congenital Deafness: JAMA Study

Ibogaine appears to treat traumatic brain injuries in veterans: Study