Antipyretic therapy reduces overheating during exercise in people with MS, reveals study
A recent study published in the Journal of Neurology found that antipyretic (fever-reducing) treatments before exercise can significantly reduce the risk of overheating, a common deterrent to physical activity in people with multiple sclerosis (pwMS). This research opens new avenues for to manage MS symptoms and enhance exercise participation among pwMS.
Multiple sclerosis is a chronic condition that affects the central nervous system and often leads to sensitivity to heat in many individuals, which in turn makes exercise and physical activity a challenge due to the risk of overheating. However, regular exercise is crucial for pwMS which offers benefits such as improved strength, mood and overall quality of life. The study explored the effectiveness of pre-exercise antipyretic treatment in managing body temperature and enhancing exercise tolerance to address the challenge of heat sensitivity.
This randomized controlled trial involved adults over the age of 18 diagnosed with relapsing-remitting MS, who reported heat sensitivity during exercise. The participants were randomly assigned to one of six sequences, and were subjected to receive doses of either aspirin, acetaminophen or a placebo before undertaking a maximal exercise test. The primary outcomes measured were changes in body temperature and total time to exhaustion (TTE), with secondary outcomes focusing on physiological and patient-reported outcomes (PROs).
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