BCG vaccine could have protective effect against Alzheimer's disease: JAMA

The Bacillus Calmette-Guérin (BCG) vaccine-which prevents tuberculosis-offers multiple beneficial effects, and it's currently a recommended therapy for non-muscle-invasive bladder cancer
Researchers have found in a new study that BCG vaccine could have protective effect against Alzheimer's disease.In a new study led by investigators at Massachusetts General Hospital (MGH) and Brigham and Women’s Hospital (BWH), treatment with the BCG vaccine was associated with a reduced risk of Alzheimer’s disease and related dementias. The findings are published in JAMA Network Open.
Although previous research has suggested a link between the BCG vaccine and a lower risk of dementia, studies were limited by size, study design, or analytical methods. To conduct a more robust study, Marc Weinberg, MD, PhD, an Instructor in Psychiatry at MGH, along with co-first authors Colin Magdamo, BS, (MGH Neurology) and Affan Zafar, MD (MGH and BWH Urology), senior author Sudeshna Das, PhD, (MGH Neurology), and colleagues followed 6,467 individuals for up to 15 years after they were diagnosed with non–muscle-invasive bladder cancer. The group included 3,388 patients who underwent BCG vaccine treatment and 3,079 who served as controls, matched by factors such as age, sex, and medical co-morbidities.
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