COGAS score helps assess neurocognitive outcomes in patients with CO poisoning: JAMA

A new study published in Journal of American Medical Association suggest that during the early stages of carbon monoxide (CO) poisoning, measuring the Glasgow Coma Scale score, age, and shock (COGAS score) may assist identify individuals at risk of poor neurocognitive sequelae.

A fundamental objective of treating acute CO poisoning is to prevent neurocognitive sequelae. There are no good score systems for predicting the likelihood of these consequences. Sung Hwa Kim and colleagues conducted this work to design and verify a unique clinical grading model that can predict poor neurocognitive outcomes following acute co poisoning.

This prognostic analysis includes derivation and validation cohorts relying on sequential patient data gathered prospectively at university hospitals in Wonju, Republic of Korea, from January 2006 to July 2021, and in Incheon, Republic of Korea, from August 2016 to June 2020. Participants comprised those aged 16 and above who had been diagnosed with co poisoning. The data was examined from October 2021 until January 2022. The neurocognitive sequelae at 4 weeks following co poisoning were of particular attention. In the derivation cohort, logistic regression models were employed to uncover predictors of poor neurocognitive outcomes. At one month following CO-exposure, outcomes were assessed using the Global Deterioration Scale [GDS] and categorized as excellent (1-3 points) or bad (4-7 points).