Diets higher in inflammatory foods associated with increased dementia risk among elderly: Study

They evaluated whether higher Dietary Inflammatory Index (DII) scores were associated with increased incidence of all-cause dementia and Alzheimer's disease (AD) dementia over 22.3 years of follow-up in the community-based Framingham Heart Study Offspring cohort.

One thousand four hundred eighty-seven participants (mean ± standard deviation, age in years 69 ± 6) completed food frequency questionnaires (FFQs) and had incident all-cause dementia and AD surveillance data available. RESULTS: Two hundred forty-six participants developed all-cause dementia (including AD, n = 187) over a median follow-up time of 13.1 years.

Higher DII scores, averaged across a maximum of three timepoints, were associated with an increased incidence of all-cause dementia and AD after adjustment for demographic, lifestyle, and clinical covariates (hazard ratio [HR] 1.21, 95% confidence interval [CI] 1.10–1.33, P < 0.001; HR 1.20, 95% CI: 1.07–1.34d, P = 0.001, respectively).

Higher DII scores were associated with a higher risk of incident all-cause dementia and AD. Although these promising findings need to be replicated and further validated, the results suggest that diets that correlate with low DII scores may prevent late-life dementia.

Highlights:

Higher Dietary Inflammatory Index (DII) scores were associated with an increased incidence of all-cause dementia.

Higher DII scores were associated with an increased incidence of Alzheimer's disease dementia.

Diets that correlate with low DII scores may prevent late-life dementia.

Reference:

van Lent DM, Mesa HG, Short MI, et al. Association between dietary inflammatory index score and incident dementia. Alzheimer's Dement. 2024; 1-11. https://doi.org/10.1002/alz.14390