Early cerebral haemorrhage a potential prognostic marker for community-acquired bacterial meningitis
Early cerebral haemorrhage (ECHO) is a potential prognostic marker for community-acquired bacterial meningitis according to a recent study published in the Frontiers in Neurology
Community-acquired bacterial meningitis in adults is associated with significant morbidity and mortality; therefore, early prognostication is important to identify severe cases and possibly allocate more intensive treatment. They hypothesized that early intracranial haemorrhage portends a poor prognosis.
Community-acquired bacterial meningitis is an infectious disease with high rates of morbidity and mortality. In clinical practice, prognostication of neurological outcomes in meningitis is difficult. On one hand, patients who are seemingly hopeless may survive and fully recover. On the other hand, deleterious complications such as stroke, brain edema, or hydrocephalus may occur and worsen outcomes. Large prospective studies set out to identify prognostic factors. As expected, advanced age, signs of more severe neurological affection, and systemic inflammation were prognostic for unfavourable outcomes. Other factors remained equivocal, e.g., both absence and presence of otitis were associated with an unfavourable outcome. While some information is available upon diagnosis, other prognostic factors, such as a positive blood culture or the causative pathogen, are available only during the course of the disease
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