Early Treatment with Sublingual Edaravone Dexborneol Enhances Recovery in acute ischemic stroke, finds study
Written By : Aditi
Medically Reviewed By : Dr. Kamal Kant Kohli
Published On 2024-02-22 12:00 GMT | Update On 2024-02-22 12:00 GMT
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Sublingual edaravone dexborneol can rapidly diffuse and absorbed through the oral mucosa after sublingual exposure. It is a multitarget brain cytoprotection which contains antioxidant and anti-inflammatory ingredients edaravone and dexborneol.
An Original Investigation published in JAMA Neurology has concluded that sublingual edaravone dexborneol can enhance the chances of achieving favorable clinical outcomes at 90 days for individuals with acute ischemic stroke.
Researchers evaluated the efficacy and safety of sublingual edaravone dexborneol on functional outcomes in patients with acute ischemic stroke (AIS) in this double-blind, placebo-controlled, multicenter, parallel-group, phase 3 RCT (June 28, 2021, to August 10, 2022) with a 90-day follow-up.
The study included participants from 33 centres in China aged 18 to 80 years, with a National Institutes of Health Stroke Scale score between 6 and 20, a total motor deficit score of 2 or greater for upper and lower limbs, a clinically diagnosed AIS symptom within 48 hours, and a modified Rankin Scale (mRS) score of 1 or less before the stroke. Patients who did not meet the eligibility criteria or declined participation were excluded.
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