Glucosamine supplementation may lowers risk of incident vascular dementia among elderly

The primary outcome measured in the study was incident vascular dementia, incident Alzheimer's disease, and incident frontotemporal dementia, respectively.

The key results of the study are:

• The median follow-up duration was 12 years.
• In this follow-up duration, vascular dementia, Alzheimer's disease, and frontotemporal dementia were developed in 1039, 1774, and 122 participants, respectively.
• Habitual glucosamine use lowered the risk of incident vascular dementia with an adjusted HR of 0.82.
• This had no association with incident Alzheimer's disease and frontotemporal dementia, with adjusted HR of 1.02 and 0.95, respectively.
• Those with concomitant calcium supplementation and those without concomitant zinc supplementation had an inverse association between habitual glucosamine use and incident vascular dementia.
• APOE ε4 dosage and baseline cognitive function did not modify the relationships of glucosamine use with incident vascular dementia or Alzheimer's disease

They concluded that regardless of APOE genotypes and baseline cognitive function, habitual glucosamine has an inverse association with incident vascular dementia in the older population.

Further reading:

https://alzres.biomedcentral.com/articles/10.1186/s13195-023-01295-6